Omega-6 fatty acids like linoleic acid are well-supplied in the diet by meat and vegetable oils. But some omega-6s can contribute to the production of inflammatory compounds such as prostaglandin E2 (PGE2), thromboxane A2 and leukotriene B4 (LTB4). GLA and omega 6 fatty acids : Gamma-linolenic acid (GLA) from borage oil, on the other hand, helps inhibit inflammatory compounds and promotes healthy prostaglandin E1 (PGE1) levels, both of which promote whole body health. Borage oil supplements are an excellent way to obtain GLA.5 GLA is the precursor to the biologically active dihomo-gamma-linolenic acid (DGLA), which may provide optimal health benefits. And our Mega GLA supplement provides 400 mg of concentrated GLA from borage oil per softgel. Augmented with sesame lignans : We’ve added 10 mg of sesame lignan extract to each softgel to help promote healthy levels of beneficial DGLA. Sesame lignans help inhibit the conversion of GLA into inflammatory arachidonic acid.8 This, in turn, inhibits the formation of other inflammatory compounds like PGE2 and LTB4 in order to support whole body health. Choose the right GLA supplement : Numerous studies document GLA’s multiple health effects. Enhancing this supplement with sesame lignans enables GLA to work much better in the body, increasing the benefit of supplemental GLA.